Investigating how RNase L affects kidney function
The role of RNase L in kidney function
This study is looking at how a protein called RNase L helps the kidneys heal after an injury, which could lead to new treatments for people with kidney problems.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10730414 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of RNase L in kidney function, particularly in the context of acute kidney injury (AKI). The study explores how RNase L influences the secretion of epidermal growth factor (EGF), which is crucial for kidney cell repair and regeneration. By examining the effects of RNase L in both healthy and injured kidneys, the research aims to clarify its dual role in promoting recovery while preventing chronic kidney disease. Patients may benefit from insights that could lead to new treatments for kidney injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced acute kidney injury or are at risk for kidney-related complications.
Not a fit: Patients with stable chronic kidney disease or those without any history of kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from acute kidney injury, potentially enhancing recovery and preventing chronic kidney disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of growth factors in kidney repair, suggesting that this approach may yield valuable insights.
Where this research is happening
Cleveland, United States
- Cleveland State University — Cleveland, United States (Active)
Researchers
- Principal investigator: Zhou, Aimin — Cleveland State University
- Study coordinator: Zhou, Aimin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.