Investigating how RNase L affects kidney function
Official title: The role of RNase L in kidney function
Funded at Cleveland State University · NIH-10730414 · Data updated 2026-11-12
This study is looking at how a protein called RNase L helps the kidneys heal after an injury, which could lead to new treatments for people with kidney problems.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $445,500 |
| NIH project number | 1R15DK135029-01A1 |
| Project ID | NIH-10730414 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced acute kidney injury or are at risk for kidney-related complications.
✕Less likely to help
Patients with stable chronic kidney disease or those without any history of kidney injury may not benefit from this research.
What this research studies
This research focuses on understanding the role of RNase L in kidney function, particularly in the context of acute kidney injury (AKI). The study explores how RNase L influences the secretion of epidermal growth factor (EGF), which is crucial for kidney cell repair and regeneration. By examining the effects of RNase L in both healthy and injured kidneys, the research aims to clarify its dual role in promoting recovery while preventing chronic kidney disease. Patients may benefit from insights that could lead to new treatments for kidney injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from acute kidney injury, potentially enhancing recovery and preventing chronic kidney disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of growth factors in kidney repair, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Zhou, Aimin — Cleveland State University
- Study coordinator: Zhou, Aimin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.