Investigating how RBPMS affects heart function and disease
Official title: RBPMS, a novel RNA splicing regulator of cardiac function and disease
Funded at Ut Southwestern Medical Center · NIH-10984736 · Data updated 2026-11-12
This study is looking at a protein called RBPMS to see how it affects heart cell function and could help protect against heart failure, which might lead to new treatments for heart conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $100,480 |
| NIH project number | 1K99HL171888-01A1 |
| Project ID | NIH-10984736 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with heart disease or those at risk of developing heart failure.
✕Less likely to help
Patients with non-cardiac conditions or those under 21 years old may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of RBPMS, a protein that regulates RNA splicing, in heart function and disease. The study examines how RBPMS influences the contractility of heart cells and its potential protective effects against heart failure. By using human stem cell-derived heart cells and animal models, the research aims to uncover the mechanisms by which RBPMS contributes to heart health and disease progression. Patients may benefit from insights gained about new therapeutic targets for heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and outcomes for patients with heart disease.
How similar studies have gone: Previous studies have shown promising results regarding the role of RNA splicing in heart function, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Gan, Peiheng — Ut Southwestern Medical Center
- Study coordinator: Gan, Peiheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.