Investigating how immune system changes and nerve growth factor issues contribute to Alzheimer's in people with Down syndrome
The role of immune deregulation and NGF dysmetabolism in the development of Alzheimer disease in individuals with Down syndrome
This study is looking at how Alzheimer's disease develops in people with Down syndrome to find new ways to spot it early and improve treatment, and it will involve tracking changes in thinking and memory over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10888861 on NIH RePORTER |
What this research studies
This research focuses on understanding the specific biological mechanisms that lead to Alzheimer's disease in individuals with Down syndrome. By examining factors such as immune system deregulation and nerve growth factor dysmetabolism, the study aims to identify new biomarkers that could help in early detection and treatment. The research will involve collaboration among experts from various institutions to gather comprehensive data on the progression of Alzheimer's in this population. Patients may be monitored for changes in cognitive function and other related symptoms over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome who are 21 years or older and may be at risk for developing Alzheimer's disease.
Not a fit: Patients without Down syndrome or those who are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and targeted treatments for Alzheimer's disease in individuals with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding Alzheimer's disease mechanisms in similar populations, indicating that this approach could yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Busciglio, Jorge a — University of California-Irvine
- Study coordinator: Busciglio, Jorge a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.