Creating a mouse model to study Alzheimer's disease in people with Down syndrome
Develop and Validate a Mouse Model for Alzheimer Disease in Down Syndrome
This study is creating a special type of mouse that mimics how Alzheimer's disease affects people with Down syndrome, so researchers can learn more about the disease and find better ways to treat it, which could help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10973514 on NIH RePORTER |
What this research studies
This research aims to develop a new mouse model that accurately represents Alzheimer's disease as it occurs in individuals with Down syndrome. By genetically modifying a specific mouse strain to include features of human genetics, the researchers will replicate key pathological characteristics of Alzheimer's, such as amyloid plaques and neurofibrillary tangles. This model will help scientists better understand the mechanisms of Alzheimer's in Down syndrome and test potential treatments. Patients may benefit from advancements in understanding and managing Alzheimer's disease through insights gained from this model.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome, particularly those over the age of 65 who are at risk for Alzheimer's disease.
Not a fit: Patients without Down syndrome or those who are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease in individuals with Down syndrome.
How similar studies have performed: Previous research has shown success in using mouse models to study Alzheimer's disease, but this specific approach for Down syndrome is novel.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Mobley, William C — University of California, San Diego
- Study coordinator: Mobley, William C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.