Immune changes and nerve growth factor problems linked to Alzheimer’s in adults with Down syndrome
The role of immune deregulation and NGF dysmetabolism in the development of Alzheimer disease in individuals with Down syndrome
Researchers are looking at how immune system changes and problems with nerve growth factor relate to Alzheimer’s in adults with Down syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11382738 on NIH RePORTER |
What this research studies
If you have Down syndrome, this project will compare people at different stages of brain changes to find biological signs tied to Alzheimer’s, focusing on immune signals and nerve growth factor (NGF). The team will use samples and data from adults with Down syndrome and partner centers to look for biomarkers inside and outside the usual amyloid/tau framework. Findings could help spot early changes that come before symptoms and point to new prevention approaches. The work builds on existing collaborations among several hospitals and research centers to combine expertise and patient resources.
Who could benefit from this research
Good fit: Adults with Down syndrome, especially those in middle age or showing early cognitive changes, would be the best fit.
Not a fit: People without Down syndrome or those with very advanced dementia are unlikely to directly benefit from this specific project.
Why it matters
Potential benefit: This work could help detect Alzheimer’s earlier in people with Down syndrome and point to new targets to prevent or slow decline.
How similar studies have performed: Previous research has documented Alzheimer-like pathology in Down syndrome and biomarker work is active, but the combined focus on immune dysregulation and NGF is relatively new.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Busciglio, Jorge a — University of California-Irvine
- Study coordinator: Busciglio, Jorge a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.