Investigating how certain proteins affect lung inflammation in ARDS
Functional Role of HIF-PHDs in ARDS
This study is looking at how certain proteins in your body help control lung inflammation during serious breathing problems like acute respiratory distress syndrome (ARDS), which can happen after surgeries or infections, to find new ways to help treat or prevent this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10917255 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific proteins, known as HIF prolyl hydroxylases (PHDs), in regulating lung inflammation during acute respiratory distress syndrome (ARDS). ARDS can occur after major surgeries or infections, leading to severe lung injury. The study aims to explore how these proteins influence the body's response to low oxygen levels and inflammation in the lungs. By examining the mechanisms behind this regulation, the research seeks to identify potential therapeutic targets to prevent or treat ARDS.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults who have experienced severe lung inflammation due to surgery or infections, particularly those related to COVID-19.
Not a fit: Patients with chronic lung diseases or those who do not have acute respiratory distress syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce lung inflammation and improve outcomes for patients with ARDS.
How similar studies have performed: Previous studies have shown promising results in understanding the role of HIFs in lung inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Eltzschig, Holger K. — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Eltzschig, Holger K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.