Investigating how certain proteins affect lung inflammation in ARDS
Official title: Functional Role of HIF-PHDs in ARDS
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10917255 · Data updated 2026-11-12
This study is looking at how certain proteins in your body help control lung inflammation during serious breathing problems like acute respiratory distress syndrome (ARDS), which can happen after surgeries or infections, to find new ways to help treat or prevent this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $664,541 |
| NIH project number | 5R01HL169519-02 |
| Project ID | NIH-10917255 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults who have experienced severe lung inflammation due to surgery or infections, particularly those related to COVID-19.
✕Less likely to help
Patients with chronic lung diseases or those who do not have acute respiratory distress syndrome may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific proteins, known as HIF prolyl hydroxylases (PHDs), in regulating lung inflammation during acute respiratory distress syndrome (ARDS). ARDS can occur after major surgeries or infections, leading to severe lung injury. The study aims to explore how these proteins influence the body's response to low oxygen levels and inflammation in the lungs. By examining the mechanisms behind this regulation, the research seeks to identify potential therapeutic targets to prevent or treat ARDS.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce lung inflammation and improve outcomes for patients with ARDS.
How similar studies have gone: Previous studies have shown promising results in understanding the role of HIFs in lung inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Eltzschig, Holger K. — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Eltzschig, Holger K.
Related research
Other NIH-funded projects on the same topics.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Lipid-gene Profiles in Septic ARDS
A Mayo Clinic team is studying how dysfunctional HDL in sepsis relates to different ARDS patient outcomes, aiming to find features that could guide better treatment.
-
Improving blood vessel repair after pediatric ARDS
Aims to better repair the lungs of children who have ARDS by delivering targeted therapy to lung blood vessels using tiny nanoparticles.
-
NOX4 links to ARDS risk and progression
Aims to understand how NOX4-driven cell damage may make some adults with ARDS worse off and how this could lead to earlier, targeted care.
-
Leading causes of death in alcoholic ARDS patients using clinical data
This project uses big clinical data and AI to find the main factors that cause death in adults with ARDS who have alcohol use issues, aiming to improve understanding and care.
-
Targeting aging-related blood vessel injury to prevent ARDS in older lungs
Aims to find ways to protect lung blood vessels in older adults to prevent dangerous lung swelling (ARDS).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.