Investigating how a specific protein affects muscle function and diseases.
Official title: The role of nuclear envelope protein NET39 in skeletal muscle function and diseases
Funded at Ut Southwestern Medical Center · NIH-11013895 · Data updated 2026-11-12
This study is looking at a protein called NET39 to understand how changes in it can cause muscle diseases like Emery-Dreifuss muscular dystrophy, and it aims to find out more about why these muscle problems happen and how we might be able to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $422,136 |
| NIH project number | 5R01AR080676-03 |
| Project ID | NIH-11013895 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Emery-Dreifuss muscular dystrophy or related muscle disorders.
✕Less likely to help
Patients with muscle diseases not related to nuclear envelope proteins may not benefit from this research.
What this research studies
This research focuses on the role of a protein called NET39 in maintaining the structure and function of muscle cells. By studying how mutations in this protein lead to diseases like Emery-Dreifuss muscular dystrophy, the researchers aim to uncover the molecular mechanisms behind muscle-specific defects. The approach includes analyzing muscle biopsies from patients and using animal models to observe the effects of NET39 deletion. This could help clarify why certain muscle diseases occur and how they can be treated.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for muscle diseases caused by nuclear envelope protein mutations.
How similar studies have gone: Previous research has shown success in understanding muscle diseases related to nuclear envelope proteins, suggesting that this approach has potential for meaningful discoveries.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Olson, Eric N — Ut Southwestern Medical Center
- Study coordinator: Olson, Eric N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.