Integrating race and ancestry to understand cancer risk and outcomes
Official title: Project 2: Integrating race, ethnicity, and genomic ancestry across GENIE to understand genetic and environmental contributions to pan-cancer risk, prognosis, and outcomes
Funded at Sloan-Kettering Inst Can Research · NIH-11415493 · Data updated 2026-11-12
A large cancer research grant aims to study how genes linked to race and ancestry influence cancer risk, progression, and patient outcomes.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 3, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $392,799 |
| NIH project number | 5P01CA275746-03 |
| Project ID | NIH-11415493 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cancer from diverse racial and ethnic backgrounds, including African American and Asian ancestry groups, who have tumor samples or clinical data available.
✕Less likely to help
This work may not directly benefit patients who do not have accessible genomic data or come from underrepresented groups where data are sparse.
What this research studies
This project looks at genetic ancestry across a pan-cancer dataset to understand why cancer outcomes differ among populations. Researchers will analyze genomic data from diverse groups to identify ancestry-related differences in mutations and environmental contributions. The goal is to improve precision oncology by tailoring prevention and treatment considerations to diverse patient populations.
Why it matters
Potential benefit: If successful, results could lead to more personalized cancer care that accounts for ancestry and genetic background.
How similar studies have gone: Previous cancer genomics work has shown ancestry-related differences; this project extends those findings across many cancer types.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Carrot-Zhang, Jian — Sloan-Kettering Inst Can Research
- Study coordinator: Carrot-Zhang, Jian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.