Harnessing the body’s response to Leptospirosis to improve diagnosis and prognosis
Official title: Harnessing the Host Response to Leptosporisis for Diagnosis and Prognosis
Funded at University of California Los Angeles · NIH-11535277 · Data updated 2026-11-12
A research program at UCLA aims to use how the body responds to leptospirosis to make better diagnoses and predict outcomes for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $62,500 |
| NIH project number | 3P01AI168148-04S4 |
| Project ID | NIH-11535277 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with suspected or confirmed leptospirosis who are treated at participating clinical centers.
✕Less likely to help
Patients without leptospirosis or with unrelated conditions may not benefit from this research.
What this research studies
This project seeks to translate how the immune system and other host signals react to leptospirosis into clearer tests and prognostic information for people with the infection. It will bring together multiple research approaches over several years to identify biomarkers and develop predictive indicators. The team will work with patient samples and clinical data to illuminate how the body’s response reflects disease severity and course. If successful, these findings could help clinicians diagnose leptospirosis earlier and tailor treatment strategies.
Why it matters
Potential benefit: If successful, patients could receive faster, more accurate diagnoses and better-guided care for leptospirosis.
How similar studies have gone: Prior studies have shown that host-response biomarkers can aid infectious disease diagnosis, but this specific approach for leptospirosis is novel and exploratory.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Haake, David a — University of California Los Angeles
- Study coordinator: Haake, David a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.