Harnessing the body's response to a dangerous infection to help diagnose and predict outcomes
Official title: Harnessing the Host Response to Leptosporisis for Diagnosis and Prognosis
Funded at University of California Los Angeles · NIH-11535237 · Data updated 2026-11-12
A large, multi-project effort aims to use how the body reacts to leptospirosis to improve diagnosis and prognosis for patients affected by this infection.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $167,117 |
| NIH project number | 3P01AI168148-04S3 |
| Project ID | NIH-11535237 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with suspected or confirmed leptospirosis who can provide samples or clinical data for analysis.
✕Less likely to help
People without leptospirosis or those not contributing samples or data may not benefit directly.
What this research studies
This grant supports a coordinated program to study how the body’s immune and physiological responses reflect leptospirosis, with efforts that could lead to better tests and prognosis tools. It involves collaboration across researchers to integrate biological signals from patients and samples to develop clinically useful indicators. The work is designed to translate findings into faster, clearer diagnoses and informed treatment decisions for people suspected of having leptospirosis. Results could help clinicians tailor care and improve outcomes for patients with this infection.
Why it matters
Potential benefit: If successful, patients with leptospirosis could receive faster and more accurate diagnoses and better-informed prognostic information.
How similar studies have gone: Related studies have shown promise in identifying host-response patterns that aid diagnosis and prognosis in infectious diseases, though this exact approach for leptospirosis is under development.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Haake, David a — University of California Los Angeles
- Study coordinator: Haake, David a
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Harnessing the body's response to leptospirosis to aid diagnosis and prognosis
This grant aims to develop new ways to detect leptospirosis earlier and predict how severe it might become by studying the body's own response.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.