Harnessing the body's response to leptospirosis to aid diagnosis and prognosis
Official title: Harnessing the Host Response to Leptosporisis for Diagnosis and Prognosis
Funded at University of California Los Angeles · NIH-11535302 · Data updated 2026-11-12
This grant aims to develop new ways to detect leptospirosis earlier and predict how severe it might become by studying the body's own response.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $62,493 |
| NIH project number | 3P01AI168148-04S5 |
| Project ID | NIH-11535302 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals suspected or confirmed to have leptospirosis who can provide biological samples for research.
✕Less likely to help
Patients without leptospirosis or those not contributing samples may not directly benefit.
What this research studies
Leptospirosis is a bacterial infection that can affect many organs. This project uses human biology and samples to identify markers in the host response that indicate infection and disease progression. The approach combines multiple research teams under a single program to translate biological insights into potential diagnostic and prognostic tools. The work is designed to move from discovery toward tests that clinicians can use to guide care.
Why it matters
Potential benefit: If successful, patients could get faster, more accurate diagnoses and better predictions of illness severity to tailor treatments.
How similar studies have gone: Previous studies showed promise in host-response markers for infectious diseases, but applying this to leptospirosis is an emerging area.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Haake, David a — University of California Los Angeles
- Study coordinator: Haake, David a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.