Inflammation resolution in aging and artery disease
Official title: Inflammation-resolution impairments in aging and atherosclerosis
Funded at Albany Medical College · NIH-11337521 · Data updated 2026-11-12
This project explores why aging makes atherosclerosis harder to resolve, and tests new therapies that boost the body’s own inflammation-resolving signals to help prevent heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $779,862 |
| NIH project number | 5R01HL170249-04 |
| Project ID | NIH-11337521 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with or at risk for atherosclerotic cardiovascular disease, particularly older adults experiencing chronic inflammation.
✕Less likely to help
If a patient does not have ASCVD or age-related inflammatory issues, they may derive little direct benefit from this specific research.
What this research studies
As people age, inflammation tends to linger and may worsen atherosclerosis. The researchers will study how aging disrupts the body’s natural ability to finish inflammation and how specialized mediators called resolvins can help restore balance. They will use aging animal models to understand changes in blood cells and signals that drive persistent inflammation, and test resolvin-based treatments to promote healing in the arteries. The goal is to identify mechanisms and therapies that work in the aging context, potentially translating into new options for older adults with ASCVD.
Why it matters
Potential benefit: If successful, the work could lead to new treatments that improve inflammation resolution and slow or prevent age-related atherosclerotic disease.
How similar studies have gone: Prior studies in animals suggest that boosting pro-resolving mediators can improve resolution of inflammation, supporting the potential for benefit in aging-related atherosclerosis.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Fredman, Gabrielle — Albany Medical College
- Study coordinator: Fredman, Gabrielle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.