How aging affects inflammation and heart disease
Official title: Inflammation-resolution impairments in aging and atherosclerosis
Funded at Albany Medical College · NIH-11083016 · Data updated 2026-11-12
This study is looking at how getting older affects inflammation in the body and how that might lead to heart problems, especially in older adults, with the hope of finding new ways to help treat heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $795,777 |
| NIH project number | 5R01HL170249-03 |
| Project ID | NIH-11083016 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who are at risk for or have been diagnosed with atherosclerotic cardiovascular disease.
✕Less likely to help
Patients who are younger and do not have any cardiovascular disease or inflammation-related conditions may not benefit from this research.
What this research studies
This research investigates how aging influences inflammation and its role in heart disease, specifically atherosclerosis. It focuses on understanding the mechanisms that lead to persistent inflammation in older adults and how this impacts cardiovascular health. The study aims to explore the balance between harmful inflammatory substances and those that promote healing, with the goal of developing new treatments for heart disease in the context of aging. By studying aged mice, researchers will identify potential therapeutic strategies to improve inflammation resolution.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart health and reduce inflammation in older patients.
How similar studies have gone: Other research has shown promising results in understanding inflammation and aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Fredman, Gabrielle — Albany Medical College
- Study coordinator: Fredman, Gabrielle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.