Investigating how premature aging affects blood vessel diseases and heart health
Official title: Premature aging disorders, metabolites, and atherosclerosis
Funded at University of Tx Md Anderson Can Ctr · NIH-10988269 · Data updated 2026-11-12
This study is looking at how certain conditions that cause premature aging can lead to heart problems, and it aims to find ways to help prevent these issues for people affected by these disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $641,069 |
| NIH project number | 5R01HL163857-03 |
| Project ID | NIH-10988269 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Hutchinson-Gilford progeria syndrome or those experiencing premature aging due to ionizing radiation exposure.
✕Less likely to help
Patients without premature aging disorders or those not affected by atherosclerosis may not benefit from this research.
What this research studies
This research focuses on understanding how premature aging disorders, such as those caused by ionizing radiation and Hutchinson-Gilford progeria syndrome, lead to accelerated blood vessel diseases like atherosclerosis and coronary artery disease. The study aims to uncover the molecular mechanisms behind these conditions, particularly how certain cellular processes contribute to vascular dysfunction. By analyzing specific metabolic pathways and their effects on endothelial cells, the research seeks to identify potential therapeutic targets to prevent heart disease in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent heart disease in patients with premature aging disorders.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of aging-related vascular diseases, indicating that this approach may lead to significant advancements.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Abe, Jun-Ichi — University of Tx Md Anderson Can Ctr
- Study coordinator: Abe, Jun-Ichi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.