How sleep affects blood health and heart disease as we age
Official title: Influence of sleep on the hematopoietic niche and atherosclerosis during aging
Funded at Icahn School of Medicine at Mount Sinai · NIH-11092133 · Data updated 2026-11-12
This study is looking at how poor sleep can affect heart health in older adults, hoping to find ways to help them sleep better and reduce their risk of heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $422,500 |
| NIH project number | 5R01HL158534-05 |
| Project ID | NIH-11092133 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing sleep disturbances and at risk for cardiovascular disease.
✕Less likely to help
Patients who are young and do not have sleep issues or cardiovascular risk factors may not benefit from this research.
What this research studies
This research investigates the relationship between sleep quality and cardiovascular health in older adults. It focuses on how sleep disruption may lead to increased risks of heart disease by affecting blood cell production and inflammation. Using advanced mouse models, the study aims to uncover the biological mechanisms linking poor sleep to cardiovascular issues, particularly in the aging population. By understanding these connections, the research seeks to identify potential interventions to improve health outcomes for older individuals.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing heart disease in older adults by improving sleep quality.
How similar studies have gone: Previous research has shown promising results in understanding the links between sleep and cardiovascular health, suggesting that this approach has potential for significant findings.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Mcalpine, Cameron Stuart — Icahn School of Medicine at Mount Sinai
- Study coordinator: Mcalpine, Cameron Stuart
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.