Inflammation after stroke and its link to later cognitive problems
Official title: Inflammation and delayed cognitive dysfunction after stroke
Funded at University of Arizona · NIH-10809797 · Data updated 2026-11-12
This grant looks at how long-term brain inflammation after a stroke might drive later thinking and memory problems in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | March 15, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $680,190 |
| NIH project number | 4R01NS131110-02 |
| Project ID | NIH-10809797 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of stroke or vascular-related brain injury may be relevant for future clinical translation and testing.
✕Less likely to help
People without stroke history or those not experiencing inflammatory changes related to VCID may not benefit.
What this research studies
Researchers at the University of Arizona are studying why people may develop cognitive difficulties after stroke. They focus on the body’s inflammatory response and how immune cells in the brain handle cholesterol and other lipids after stroke. The study uses animal models to explore cellular and molecular processes that could lead to lasting brain changes, aiming to connect these findings to human disease. The goal is to identify targets that could prevent or lessen post-stroke cognitive decline.
Why it matters
Potential benefit: If successful, findings could lead to new treatments to reduce inflammation and protect thinking skills after stroke.
How similar studies have gone: Prior work has shown a link between post-stroke inflammation and cognitive issues, supporting the potential for meaningful advances in this area.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Doyle, Kristian Paul — University of Arizona
- Study coordinator: Doyle, Kristian Paul
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.