The link between inflammation and cognitive problems after a stroke
Inflammation and delayed cognitive dysfunction after stroke
['FUNDING_OTHER'] · UNIVERSITY OF ARIZONA · NIH-10621096
This study is looking at how inflammation after a stroke might cause memory and thinking problems later on, and it’s for stroke survivors who want to help us understand how this process works.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-10621096 on ClinicalTrials.gov |
What this research studies
This research investigates how inflammation following a stroke may lead to delayed cognitive dysfunction. It focuses on understanding the chronic inflammatory response that occurs after a stroke and how it resembles processes seen in atherosclerosis. By examining the role of macrophages and microglia in processing lipids and producing neurotoxic substances, the study aims to uncover the mechanisms behind cognitive impairment in stroke survivors. Patients may be involved in assessments that help identify these inflammatory responses and their effects on cognitive health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced a stroke.
Not a fit: Patients who have not had a stroke or those with pre-existing severe cognitive impairment unrelated to stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that mitigate cognitive decline in stroke survivors by targeting inflammation.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOYLE, KRISTIAN PAUL — UNIVERSITY OF ARIZONA
- Study coordinator: DOYLE, KRISTIAN PAUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease