The link between inflammation and cognitive problems after a stroke
Official title: Inflammation and delayed cognitive dysfunction after stroke
Funded at University of Arizona · NIH-10621096 · Data updated 2026-11-12
This study is looking at how inflammation after a stroke might cause memory and thinking problems later on, and it’s for stroke survivors who want to help us understand how this process works.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | March 15, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,016,915 |
| NIH project number | 1RF1NS131110-01 |
| Project ID | NIH-10621096 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have experienced a stroke.
✕Less likely to help
Patients who have not had a stroke or those with pre-existing severe cognitive impairment unrelated to stroke may not benefit from this research.
What this research studies
This research investigates how inflammation following a stroke may lead to delayed cognitive dysfunction. It focuses on understanding the chronic inflammatory response that occurs after a stroke and how it resembles processes seen in atherosclerosis. By examining the role of macrophages and microglia in processing lipids and producing neurotoxic substances, the study aims to uncover the mechanisms behind cognitive impairment in stroke survivors. Patients may be involved in assessments that help identify these inflammatory responses and their effects on cognitive health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that mitigate cognitive decline in stroke survivors by targeting inflammation.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Doyle, Kristian Paul — University of Arizona
- Study coordinator: Doyle, Kristian Paul
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.