In situ skin regeneration and blood-vessel growth for full-thickness burns
Official title: In Situ Skin Regeneration and Angiogenesis for Full-Thickness Burns
Funded at Ohio State University · NIH-11377385 · Data updated 2026-11-12
Aims to help people with severe burns by using an off-the-shelf skin substitute plus spray-on cells to close wounds quickly and reduce infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $545,256 |
| NIH project number | 5R01AR080946-04 |
| Project ID | NIH-11377385 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with full-thickness burns where donor skin is limited and rapid closure is critical.
✕Less likely to help
Patients with burns not requiring rapid closure or those not matching the studied model may see limited benefit.
What this research studies
If you have a full-thickness burn, this project tests a new approach that combines a ready-made dermal scaffold with spray-on skin cells to promote fast, lasting wound closure. The team uses an allogeneic dermal template and rapid-release growth factors to improve cell adhesion and blood vessel formation in the wounded area. The goal is to shorten healing time, lower infection risk, and reduce scarring, by enhancing how well the skin regenerates at the injury site. The work is done in a preclinical/ translational setting to move toward real-world use in burn patients.
Why it matters
Potential benefit: If successful, patients with massive burns could heal faster, have fewer infections, and regain skin function sooner.
How similar studies have gone: This approach builds on prior work with cultured epithelial autografts and regenerative dermal templates, showing potential but needing validation in a rapid-closure context.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Powell, Heather M — Ohio State University
- Study coordinator: Powell, Heather M
Related research
Other NIH-funded projects on the same topics.
-
New Ways to Heal Severe Burns
This project aims to find faster and more effective ways to heal severe burns by helping the body regrow skin directly on the wound.
-
New grafts to treat severe burn injuries
This study is testing a new type of skin graft that helps heal deep burns by not only supporting new tissue growth but also releasing medicine to prevent infections, making it a great option for people with serious burn injuries.
-
Improving skin healing for severe burn injuries
This study is testing a new way to help people with deep burns heal faster by using special skin substitutes and their own skin cells, making it easier and safer for them to recover.
-
Impact of wildfire and prescribed burn smoke on heart and lung health in Reno, NV
This study is looking at how smoke from wildfires and controlled burns affects the health of people living in Reno, NV, especially their heart and lung health, by examining medical records and smoke details to better understand the risks for both kids and adults in the area.
-
Early detection of sepsis-related blood clotting problems in severe burn patients
This study tests how well the JAAM-2 score can detect sepsis-induced coagulopathy early in adults with severe burns who develop sepsis in the ICU.
-
THERAVEX Tissue Care Spray Plus for Healing of Skin Wounds and Ulcers
This observational review tests whether THERAVEX Tissue Care Spray Plus, used with standard wound care, helps heal various skin wounds and chronic ulcers in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.