Improving skin healing for severe burn injuries
Official title: In Situ Skin Regeneration and Angiogenesis for Full-Thickness Burns
Funded at Ohio State University · NIH-10907425 · Data updated 2026-11-12
This study is testing a new way to help people with deep burns heal faster by using special skin substitutes and their own skin cells, making it easier and safer for them to recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $575,603 |
| NIH project number | 5R01AR080946-02 |
| Project ID | NIH-10907425 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from full-thickness burns who require urgent treatment to promote skin regeneration.
✕Less likely to help
Patients with superficial burns or those who do not require skin grafting may not benefit from this research.
What this research studies
This research focuses on developing a new method for treating full-thickness burns by enhancing the body's ability to regenerate skin. It utilizes a combination of allogeneic dermal substitutes and autologous cell sprays to promote faster wound closure and improve the survival of skin cells. The approach aims to address the challenges of current treatments, which often rely on fragile skin grafts that take weeks to prepare. By using advanced techniques, the research seeks to reduce infection risks and improve healing outcomes for burn patients.
Why it matters
Potential benefit: If successful, this research could lead to faster and more effective healing for patients with severe burn injuries, reducing complications and improving quality of life.
How similar studies have gone: Previous research has shown promise in using engineered skin and cell therapies for wound healing, indicating potential success for this novel approach.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Powell, Heather M — Ohio State University
- Study coordinator: Powell, Heather M
Related research
Other NIH-funded projects on the same topics.
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In situ skin regeneration and blood-vessel growth for full-thickness burns
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This study is looking at how smoke from wildfires and controlled burns affects the health of people living in Reno, NV, especially their heart and lung health, by examining medical records and smoke details to better understand the risks for both kids and adults in the area.
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This study tests how well the JAAM-2 score can detect sepsis-induced coagulopathy early in adults with severe burns who develop sepsis in the ICU.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.