New Ways to Heal Severe Burns
Official title: In Situ Skin Regeneration and Angiogenesis for Full-Thickness Burns
Funded at Ohio State University · NIH-11121087 · Data updated 2026-11-12
This project aims to find faster and more effective ways to heal severe burns by helping the body regrow skin directly on the wound.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $509,207 |
| NIH project number | 5R01AR080946-03 |
| Project ID | NIH-11121087 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients suffering from massive full-thickness burn injuries who require rapid wound closure would be the ideal candidates for this future treatment.
✕Less likely to help
Patients with minor burns or those whose wounds can be effectively treated with existing methods may not directly benefit from this specific advanced regenerative approach.
What this research studies
For patients with severe burns, finding enough healthy skin for grafts is a major challenge, and current treatments can be fragile and take a long time to prepare. This project is developing a new approach that uses a special template and a spray of a patient's own skin cells to help wounds close quickly. The goal is to improve how these cells attach and survive, and to encourage new blood vessel growth, which are all vital for successful healing. This could mean faster recovery and better outcomes for burn survivors.
Why it matters
Potential benefit: If successful, this approach could lead to quicker healing, reduced risk of infection, and improved recovery for patients with severe full-thickness burns.
How similar studies have gone: While current methods for full-thickness burns have limitations, this project builds upon emerging technologies and recent team developments in regenerative platforms, suggesting a novel yet informed approach.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Powell, Heather M — Ohio State University
- Study coordinator: Powell, Heather M
Related research
Other NIH-funded projects on the same topics.
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In situ skin regeneration and blood-vessel growth for full-thickness burns
Aims to help people with severe burns by using an off-the-shelf skin substitute plus spray-on cells to close wounds quickly and reduce infections.
-
New grafts to treat severe burn injuries
This study is testing a new type of skin graft that helps heal deep burns by not only supporting new tissue growth but also releasing medicine to prevent infections, making it a great option for people with serious burn injuries.
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Improving skin healing for severe burn injuries
This study is testing a new way to help people with deep burns heal faster by using special skin substitutes and their own skin cells, making it easier and safer for them to recover.
-
Impact of wildfire and prescribed burn smoke on heart and lung health in Reno, NV
This study is looking at how smoke from wildfires and controlled burns affects the health of people living in Reno, NV, especially their heart and lung health, by examining medical records and smoke details to better understand the risks for both kids and adults in the area.
-
Early detection of sepsis-related blood clotting problems in severe burn patients
This study tests how well the JAAM-2 score can detect sepsis-induced coagulopathy early in adults with severe burns who develop sepsis in the ICU.
-
THERAVEX Tissue Care Spray Plus for Healing of Skin Wounds and Ulcers
This observational review tests whether THERAVEX Tissue Care Spray Plus, used with standard wound care, helps heal various skin wounds and chronic ulcers in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.