New grafts to treat severe burn injuries
Official title: PHMB-Impregnated Acellular Biologic Grafts for Treatment of Third-Degree Burns
Funded at Bioaesthetics Corporation · NIH-10912770 · Data updated 2026-11-12
This study is testing a new type of skin graft that helps heal deep burns by not only supporting new tissue growth but also releasing medicine to prevent infections, making it a great option for people with serious burn injuries.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bioaesthetics Corporation NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | January 18, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,130,527 |
| NIH project number | 5R44GM140660-03 |
| Project ID | NIH-10912770 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from third-degree burns requiring medical intervention.
✕Less likely to help
Patients with minor burns or those who do not require surgical intervention may not benefit from this research.
What this research studies
This research focuses on developing a drug-eluting acellular dermal graft designed for the single-stage reconstruction of full-thickness burns. It aims to improve healing outcomes for burn patients by providing a scaffold that supports tissue regeneration while simultaneously releasing therapeutic agents to prevent infections, which are common complications in burn healing. The graft is created using a patented method that removes cells and immunogens from donor tissue, allowing for better integration with the patient's body. The project is currently assessing the feasibility of this innovative approach in treating third-degree burns.
Why it matters
Potential benefit: If successful, this research could significantly enhance healing and reduce complications for patients with severe burn injuries.
How similar studies have gone: Other research has shown promise in using acellular grafts for wound healing, but this specific approach with drug-eluting properties is relatively novel.
Where this research is happening
-
Bioaesthetics Corporation
Durham, United States Active
Researchers
- Principal investigator: Blum, Juliana Lyn — Bioaesthetics Corporation
- Study coordinator: Blum, Juliana Lyn
Related research
Other NIH-funded projects on the same topics.
-
In situ skin regeneration and blood-vessel growth for full-thickness burns
Aims to help people with severe burns by using an off-the-shelf skin substitute plus spray-on cells to close wounds quickly and reduce infections.
-
New Ways to Heal Severe Burns
This project aims to find faster and more effective ways to heal severe burns by helping the body regrow skin directly on the wound.
-
Improving skin healing for severe burn injuries
This study is testing a new way to help people with deep burns heal faster by using special skin substitutes and their own skin cells, making it easier and safer for them to recover.
-
Impact of wildfire and prescribed burn smoke on heart and lung health in Reno, NV
This study is looking at how smoke from wildfires and controlled burns affects the health of people living in Reno, NV, especially their heart and lung health, by examining medical records and smoke details to better understand the risks for both kids and adults in the area.
-
Early detection of sepsis-related blood clotting problems in severe burn patients
This study tests how well the JAAM-2 score can detect sepsis-induced coagulopathy early in adults with severe burns who develop sepsis in the ICU.
-
THERAVEX Tissue Care Spray Plus for Healing of Skin Wounds and Ulcers
This observational review tests whether THERAVEX Tissue Care Spray Plus, used with standard wound care, helps heal various skin wounds and chronic ulcers in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.