Improving cognitive function in mice with multi-infarct dementia
CYP2C11 Overexpression targeting peri-lesion astrocytes to improve cognitive function in mice with multi-infarct dementia
This study is exploring a new way to help improve blood flow and reduce inflammation in the brains of mice with multi-infarct dementia, which is a type of memory and thinking problem caused by blood vessel issues, by using a special virus to boost a helpful enzyme in brain cells, and it aims to find the best dose for better brain health and function.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11116232 on NIH RePORTER |
What this research studies
This research investigates a new approach to enhance blood flow and reduce inflammation in the brain of mice suffering from multi-infarct dementia, a common type of vascular cognitive impairment. By using a specific virus to increase the production of a beneficial enzyme in brain cells, the study aims to improve cognitive function and overall brain health. The research will involve testing different doses of this treatment to find the most effective one and observing its long-term effects on brain function. This approach focuses on targeting specific brain cells to minimize side effects and maximize therapeutic benefits.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals experiencing cognitive decline associated with multi-infarct dementia.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to vascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve cognitive function in patients with multi-infarct dementia.
How similar studies have performed: While this specific approach is novel, similar strategies targeting neuroinflammation and blood flow have shown promise in other studies.
Where this research is happening
East Lansing, United States
- Henry Ford Health + Michigan State University Health Sciences — East Lansing, United States (Active)
Researchers
- Principal investigator: Liu, Zhongwu — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Liu, Zhongwu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.