Exploring how personalized diets can help prevent Alzheimer's dementia.
Official title: Towards Precision Nutrition for Alzheimer's Dementia Prevention: A Prospective Study of Dietary Patterns, the Gut Microbiome and Cognitive Function
Funded at Brigham and Women's Hospital · NIH-11086861 · Data updated 2026-11-12
This study is looking at how what you eat and the bacteria in your gut might affect your brain health, especially in preventing Alzheimer's, and it’s for people who want to learn how personalized diets could help keep their minds sharp as they age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $851,108 |
| NIH project number | 5R01AG077489-04 |
| Project ID | NIH-11086861 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are interested in dietary interventions for cognitive health.
✕Less likely to help
Patients under the age of 65 or those without concerns about cognitive health may not benefit from this research.
What this research studies
This research investigates the relationship between dietary patterns, gut microbiome, and cognitive function in the context of Alzheimer's dementia prevention. It aims to develop personalized dietary approaches by analyzing how individual gut microbiomes interact with different diets to influence cognitive health. The study will utilize a prospective design, collecting data over several years to understand these complex interactions better. Participants will be monitored to see how tailored dietary changes can impact their cognitive function and overall health.
Why it matters
Potential benefit: If successful, this research could lead to personalized dietary recommendations that significantly reduce the risk of developing Alzheimer's dementia.
How similar studies have gone: Previous studies have shown promise in using dietary interventions for cognitive health, but this approach of integrating gut microbiome analysis is relatively novel.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Wang, Dong — Brigham and Women's Hospital
- Study coordinator: Wang, Dong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.