Improving blood vessel creation for tissue transplants using 3D printing
Official title: Optimizing Therapeutic Revascularization by Endothelial Cell Transplantation
Funded at Yale University · NIH-11063255 · Data updated 2026-11-12
This study is exploring new ways to 3D print blood vessels using special materials and human cells to help make organ transplants more successful and reduce the chances of complications for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $610,385 |
| NIH project number | 5R01HL169238-02 |
| Project ID | NIH-11063255 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals requiring tissue transplants, particularly those with conditions that lead to donor organ shortages.
✕Less likely to help
Patients who do not require tissue transplants or have conditions that do not involve vascular issues may not benefit from this research.
What this research studies
This research focuses on developing advanced techniques for creating blood vessels through 3D printing to improve tissue transplantation outcomes. By using bioengineered materials and human cells, the team aims to create a complex microvascular system that can effectively support grafts and reduce the risk of immune rejection. The approach involves optimizing bioinks to enhance the formation of blood vessels and using synthetic skin models to test these innovations. Patients may benefit from improved transplant success rates and reduced complications.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer tissue transplants for patients in need.
How similar studies have gone: Previous research in tissue engineering and 3D printing has shown promising results, indicating that this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Pober, Jordan S — Yale University
- Study coordinator: Pober, Jordan S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.