Identifying RNA elements that control cell division processes
Official title: High-throughput experimental and computational identification of RNA elements that regulate trafficking to midbodies
Funded at University of Colorado Denver · NIH-10995006 · Data updated 2026-11-12
This study is looking at how certain parts of messenger RNA help control where proteins go during cell division, which is really important for healthy tissue growth, and it could help us understand problems like aneuploidy that happen when cells don’t divide correctly.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $37,912 |
| NIH project number | 1F31GM155957-01 |
| Project ID | NIH-10995006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to genomic instability or aneuploidy.
✕Less likely to help
Patients with stable genomic conditions or those not affected by cell division-related disorders may not benefit from this research.
What this research studies
This research investigates how specific RNA elements within messenger RNA (mRNA) influence the localization of proteins during cell division, particularly at a structure called the midbody. By using advanced experimental and computational techniques, the study aims to uncover the mechanisms that regulate the separation of dividing cells, which is crucial for proper tissue development and function. The research focuses on understanding how these RNA elements interact with proteins to ensure accurate cell division and prevent genomic instability. Patients may benefit from insights gained into the processes that lead to conditions like aneuploidy, which can result from errors in cell division.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases associated with cell division errors, such as cancer.
How similar studies have gone: While the specific focus on midbody RNA localization is novel, similar approaches in understanding RNA localization and its effects on cell division have shown promise in other studies.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Vaeth, Katherine F — University of Colorado Denver
- Study coordinator: Vaeth, Katherine F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.