Identifying pre-sepsis opportunities for early, targeted intervention
Funded at Kaiser Foundation Research Institute · NIH-11380889 · Data updated 2026-11-12
Aims to use advanced computer methods and real-time health data to spot people at risk of sepsis before it worsens, so clinicians can act sooner in the emergency and pre-hospital settings.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kaiser Foundation Research Institute NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project start | August 1, 2018 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $461,778 |
| NIH project number | 5R35GM128672-09 |
| Project ID | NIH-11380889 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients at risk for infection who may present to the Emergency Department or pre-hospital settings and whose data can be captured in electronic health records.
✕Less likely to help
Patients without sepsis risk who do not interact with EHR-based screening may not benefit from the intervention.
What this research studies
This project uses electronic health records and AI to study how sepsis starts and progresses, with a focus on pre-hospital signals. It will test and validate prediction models in real-time clinical systems and explore additional screening tools to identify high-risk patients earlier. The study combines informatics, machine learning, and clinical workflows to design new pre-sepsis care pathways. If successful, it could lead to earlier treatment and better survival for patients at risk of sepsis.
Why it matters
Potential benefit: Could enable earlier detection and intervention for sepsis, potentially reducing mortality and improving outcomes.
How similar studies have gone: Previous work has identified pre-sepsis signals; this renewal aims to validate and extend those findings in real-time clinical platforms.
Where this research is happening
-
Kaiser Foundation Research Institute
Oakland, United States Active
Researchers
- Principal investigator: Liu, Vincent — Kaiser Foundation Research Institute
- Study coordinator: Liu, Vincent
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.