How proteins assemble to perform cellular functions
Official title: Mechanisms of septin assembly that shape cellular function
Funded at University of Colorado Denver · NIH-10993094 · Data updated 2026-11-12
This study is looking at how certain proteins called septins come together to help our cells work properly, using yeast to learn more about how this happens and why it matters for understanding diseases related to septin changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $335,392 |
| NIH project number | 5R35GM148198-03 |
| Project ID | NIH-10993094 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations affecting septin proteins or related cellular processes.
✕Less likely to help
Patients with conditions unrelated to septin function or cellular assembly processes may not benefit from this research.
What this research studies
This research investigates the mechanisms by which septin proteins assemble into complexes that are crucial for various cellular functions. Using budding yeast as a model organism, the study aims to understand how specific septin subunits are selected and how molecular chaperones assist in this assembly process. By exploring these fundamental biological processes, the research seeks to fill significant knowledge gaps in cell biology that could have implications for understanding diseases linked to septin mutations.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular functions and potential therapeutic targets for diseases caused by septin mutations.
How similar studies have gone: Other research has shown success in understanding protein assembly mechanisms, but this specific focus on septin proteins is relatively novel.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Mcmurray, Michael a — University of Colorado Denver
- Study coordinator: Mcmurray, Michael a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.