How oxygen and workload affect heart cell growth
Official title: Supply and Demand: Oxygen and Workload Regulate Cardiomyocyte Proliferation
Funded at Ut Southwestern Medical Center · NIH-11013978 · Data updated 2026-11-12
This study is looking at how oxygen and physical activity affect the growth of heart muscle cells, with the goal of finding ways to help adult hearts heal better, which could lead to new treatments for heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $934,989 |
| NIH project number | 5R35HL166563-03 |
| Project ID | NIH-11013978 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults suffering from heart failure or other cardiac conditions.
✕Less likely to help
Patients with non-cardiac related health issues or those who are not experiencing heart failure may not benefit from this research.
What this research studies
This research investigates how oxygen levels and physical workload influence the growth and regeneration of heart muscle cells, known as cardiomyocytes. By understanding the mechanisms that allow newborn mammals to regenerate heart tissue, the study aims to uncover ways to enhance the heart's ability to heal itself in adults. The approach involves examining the cell cycle and proliferation of cardiomyocytes, which could lead to new therapies for heart failure. Patients may benefit from insights that could improve treatments for heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance heart regeneration and improve outcomes for patients with heart failure.
How similar studies have gone: Previous research has shown promise in enhancing heart regeneration through various cell therapies, suggesting that this approach could yield significant advancements.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Sadek, Hesham — Ut Southwestern Medical Center
- Study coordinator: Sadek, Hesham
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.