How maternal metabolic issues affect early embryo development
Official title: Investigating how maternal metabolic dysfunction impacts mammalian gastrulation
Funded at Yale University · NIH-10995593 · Data updated 2026-11-12
This study looks at how a mother's metabolic health can influence the early development of her embryos, especially during a crucial stage called gastrulation, to help understand why some pregnancies may not progress as expected.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $33,958 |
| NIH project number | 1F31HD116488-01 |
| Project ID | NIH-10995593 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adult women with known metabolic dysfunctions or genetic mutations affecting metabolism.
✕Less likely to help
Patients who are not pregnant or do not have metabolic dysfunctions may not receive any benefit from this research.
What this research studies
This research investigates the impact of maternal metabolic dysfunction on the early stages of embryo development, specifically during gastrulation. It focuses on how changes in the maternal metabolic environment, particularly due to specific genetic mutations, can affect the viability and development of embryos. By modeling these metabolic disruptions in adult females, the research aims to understand the cellular and molecular mechanisms that lead to developmental delays and failures in forming essential body structures. This could provide insights into the causes of early pregnancy loss and potential interventions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of early pregnancy loss, benefiting women experiencing difficulties in maintaining pregnancies.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown that understanding metabolic environments can influence developmental outcomes.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Bergmann, Jenna — Yale University
- Study coordinator: Bergmann, Jenna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.