How maternal metabolic issues affect early embryo development
Investigating how maternal metabolic dysfunction impacts mammalian gastrulation
This study looks at how a mother's metabolic health can influence the early development of her embryos, especially during a crucial stage called gastrulation, to help understand why some pregnancies may not progress as expected.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10995593 on NIH RePORTER |
What this research studies
This research investigates the impact of maternal metabolic dysfunction on the early stages of embryo development, specifically during gastrulation. It focuses on how changes in the maternal metabolic environment, particularly due to specific genetic mutations, can affect the viability and development of embryos. By modeling these metabolic disruptions in adult females, the research aims to understand the cellular and molecular mechanisms that lead to developmental delays and failures in forming essential body structures. This could provide insights into the causes of early pregnancy loss and potential interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include adult women with known metabolic dysfunctions or genetic mutations affecting metabolism.
Not a fit: Patients who are not pregnant or do not have metabolic dysfunctions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of early pregnancy loss, benefiting women experiencing difficulties in maintaining pregnancies.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown that understanding metabolic environments can influence developmental outcomes.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Bergmann, Jenna — Yale University
- Study coordinator: Bergmann, Jenna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.