How daily biological rhythms affect heart function and arrhythmias
Official title: Circadian Regulation of Cardiac Electrophysiology
Funded at University of Kentucky · NIH-11135367 · Data updated 2026-11-12
This study is looking at how our body's internal clock affects heart health and the risk of irregular heartbeats, hoping to find new ways to prevent heart problems for people who might be affected by these rhythms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | July 9, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $614,817 |
| NIH project number | 5R01HL172813-02 |
| Project ID | NIH-11135367 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cardiovascular disease who experience arrhythmias or have a family history of sudden cardiac death.
✕Less likely to help
Patients without cardiovascular disease or those who do not experience arrhythmias may not benefit from this research.
What this research studies
This research investigates how the body's internal clock influences heart function and the risk of arrhythmias, which are irregular heartbeats. By studying the molecular mechanisms that regulate heart-related genes throughout the day, the researchers aim to understand how disruptions in these rhythms can lead to serious heart conditions. The study will utilize advanced techniques like bioluminescence assays and gene expression analysis to uncover the connections between circadian rhythms and cardiac health. Patients may benefit from insights that could lead to new prevention strategies for heart issues linked to circadian misalignment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing arrhythmias and sudden cardiac death in patients with cardiovascular disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of circadian rhythms in various health conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Delisle, Brian P — University of Kentucky
- Study coordinator: Delisle, Brian P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.