How circadian rhythms affect heart cell size and function
Official title: Circadian Regulation of Cardiomyocyte Size and Function
Funded at University of Kentucky · NIH-11032914 · Data updated 2026-11-12
This study is looking at how our body's internal clock affects heart cells and how things like poor sleep or working odd hours might lead to heart issues, helping us understand why some people with certain genetic traits might be more at risk.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $143,829 |
| NIH project number | 1K01HL177045-01 |
| Project ID | NIH-11032914 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing heart issues potentially related to irregular sleep patterns or circadian rhythm disturbances.
✕Less likely to help
Patients with stable heart conditions not influenced by circadian rhythms or those without sleep-related issues may not benefit from this research.
What this research studies
This research investigates how the body's internal clock influences the size and function of heart cells, known as cardiomyocytes. By using advanced cell models, the study aims to understand the mechanisms behind how disruptions in sleep patterns, such as irregular sleep or shift work, can lead to heart problems like arrhythmias and heart attacks. The researchers will explore whether genetic mutations that affect heart cell size also disrupt the natural rhythms of these cells. This approach will provide insights into the independent functioning of cardiomyocyte circadian clocks, separate from the brain's influence.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating heart conditions linked to circadian rhythm disruptions.
How similar studies have gone: Previous research has shown that circadian rhythm disruptions can lead to significant heart issues, indicating that this area of study has potential for impactful findings.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Blair, Cheavar — University of Kentucky
- Study coordinator: Blair, Cheavar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.