How Chlamydia affects the host cell's structure and function
Official title: Chlamydia type III effectors affecting the host actin-based cytoskeleton
Funded at University of Kentucky · NIH-11007237 · Data updated 2026-11-12
This study looks at how the Chlamydia bacteria change the way our cells work to help themselves survive and grow, and it aims to find new ways to treat Chlamydia infections that could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | February 6, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $543,958 |
| NIH project number | 5R01AI175220-03 |
| Project ID | NIH-11007237 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with Chlamydia infections or are at risk for such infections.
✕Less likely to help
Patients who do not have Chlamydia infections or related conditions may not receive any benefit from this research.
What this research studies
This research investigates how the bacteria Chlamydia trachomatis manipulates the host's actin-based cytoskeleton to facilitate its own survival and replication. By using specific Chlamydia effectors, the study aims to understand the molecular mechanisms that allow these bacteria to alter host cell functions. The research employs animal models to explore how these interactions affect cellular processes and the immune response. Patients may benefit from insights gained about Chlamydia infections and potential new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Chlamydia infections and a better understanding of how to combat related diseases.
How similar studies have gone: Previous research has shown success in understanding bacterial manipulation of host cell processes, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Fields, Kenneth a — University of Kentucky
- Study coordinator: Fields, Kenneth a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.