How certain bacteria help Group B Streptococcus colonize mucosal surfaces
Official title: Polymicrobial Interactions that Facilitate Mucosal Colonization by Group B Streptococcus
Funded at University of Colorado Denver · NIH-11125978 · Data updated 2026-11-12
This study is looking at how a bacteria called Group B Streptococcus (GBS) interacts with other germs in the body during pregnancy, to help find better ways to prevent infections in moms and their babies.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | June 26, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $195,000 |
| NIH project number | 5R21AI186346-02 |
| Project ID | NIH-11125978 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women and newborns, particularly those at risk for Group B Streptococcus infections.
✕Less likely to help
Patients who are not pregnant or do not have newborns may not receive direct benefits from this research.
What this research studies
This research investigates how Group B Streptococcus (GBS), a type of bacteria that can cause serious infections, interacts with other microorganisms in the body, particularly during pregnancy. The study focuses on understanding how these interactions affect GBS colonization in the gastrointestinal and female reproductive tracts, which is crucial for preventing adverse pregnancy outcomes and infections in newborns. By using a mouse model, researchers aim to uncover the mechanisms that allow GBS to persist and thrive in these environments, potentially leading to better prevention strategies for infections.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing infections caused by Group B Streptococcus in pregnant women and newborns.
How similar studies have gone: Previous microbiome studies have shown success in understanding bacterial interactions, suggesting that this research could build on established findings.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Doran, Kelly S — University of Colorado Denver
- Study coordinator: Doran, Kelly S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.