How cell interactions affect thoracic aorta diseases
Official title: Dynamic Cell-Matrix Interactions Dictate Thoracic Aortopathy
Funded at Yale University · NIH-11015428 · Data updated 2026-11-12
This study is looking at how cells and their surrounding support structures in the thoracic aorta, which can lead to serious issues like aneurysms and dissections, work together and affect the strength of the aorta, with the goal of finding better treatments to help patients stay healthy.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 15, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $2,508,095 |
| NIH project number | 1P01HL169168-01A1 |
| Project ID | NIH-11015428 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with thoracic aortic diseases, particularly those with genetic predispositions.
✕Less likely to help
Patients with thoracic aortopathy not linked to genetic factors may not benefit from this research.
What this research studies
This research investigates the role of cell and extracellular matrix interactions in thoracic aortopathy, which includes conditions like aneurysms and dissections. The team aims to understand how these interactions affect the structural integrity of the thoracic aorta, potentially leading to serious complications. By examining the mechanical sensing and regulation of cells within the aorta, the research seeks to identify ways to improve medical treatments and patient outcomes. The approach combines genetic insights with biomechanical analysis to develop better therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients with thoracic aortopathy.
How similar studies have gone: Previous research has shown promise in understanding cell-matrix interactions in vascular diseases, suggesting potential for success in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Humphrey, Jay D. — Yale University
- Study coordinator: Humphrey, Jay D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.