How breathing control changes with low oxygen exposure
Official title: Cellular Mechanisms of Acute-Intermittent Hypercapnic-Hypoxia Induced Phrenic Motor Plasticity
Funded at University of Florida · NIH-10996389 · Data updated 2026-11-12
This study is looking at how the breathing system in our bodies adjusts when we don't get enough oxygen, using rats to learn more about how we might improve breathing treatments for people with conditions like spinal cord injuries or ALS.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 13, 2024 |
| Project end | September 12, 2027 |
| Funding year | 2024 |
| Award (this year) | $73,828 |
| NIH project number | 1F32HL176048-01 |
| Project ID | NIH-10996389 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with spinal cord injuries or amyotrophic lateral sclerosis (ALS) who experience breathing difficulties.
✕Less likely to help
Patients with stable respiratory function or those not affected by conditions related to breathing control may not benefit from this research.
What this research studies
This research investigates how the nervous system that controls breathing adapts to experiences of low oxygen levels. Using anesthetized rats, the study monitors the activity of the phrenic nerve, which is crucial for diaphragm muscle function and breathing. The focus is on understanding two pathways that influence breathing plasticity when exposed to intermittent low oxygen, which may lead to improved treatments for conditions like spinal cord injuries or ALS. By exploring these mechanisms, the research aims to find ways to enhance respiratory function through targeted interventions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve breathing and motor functions in patients with respiratory challenges.
How similar studies have gone: Previous research has shown promise in using similar approaches to enhance respiratory function, indicating potential for success in this area.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Butenas, Alec Lloyd Edward — University of Florida
- Study coordinator: Butenas, Alec Lloyd Edward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.