How bones respond to the body’s demand during aerobic exercise
Official title: Determining mechanisms of bone remodeling response to high metabolic demands of aerobic exercise
Funded at University of Michigan at Ann Arbor · NIH-11417943 · Data updated 2026-11-12
This grant explores how bone changes when we exercise aerobically, like running or cycling, to help people understand how to protect bone health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 19, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $615,145 |
| NIH project number | 5R01AR083895-02 |
| Project ID | NIH-11417943 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals who regularly engage in aerobic activities (e.g., runners, cyclists) or who have conditions affecting bone health.
✕Less likely to help
People who do not engage in aerobic exercise or have unrelated bone conditions may see limited relevance.
What this research studies
Researchers at the University of Michigan will study how bones respond to the metabolic stress of aerobic exercise and how this interacts with the forces muscles place on bone. The project looks beyond strength training to see why bone may be resorbed more during aerobic activity and how to balance that with bone formation. Using human-relevant models and precise assays, the study aims to identify the cell sources and purposes of the elevated bone resorption marker CTX during aerobic activity. The findings could guide personalized exercise recommendations for bone health in people with high metabolic demands or energy limitations.
Why it matters
Potential benefit: If successful, findings could lead to more accurate exercise guidelines to protect and improve bone health during aerobic activity.
How similar studies have gone: Prior research shows a pro-resorptive response during aerobic exercise, but this project seeks to clarify mechanisms and sources.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Kozloff, Kenneth M — University of Michigan at Ann Arbor
- Study coordinator: Kozloff, Kenneth M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.