Exploring how different forms of a protein affect bone growth
Official title: Different Roles for Colony Stimulating Factor 1 Isoforms in Anabolic Therapy for Low Bone Mass
Funded at Yale University · NIH-10883549 · Data updated 2026-11-12
This study is looking at how two types of a protein called Colony Stimulating Factor 1 can help bones grow better when a hormone called PTH is present, which could lead to new treatments for people with low bone mass.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 10, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $639,520 |
| NIH project number | 5R01AR081074-02 |
| Project ID | NIH-10883549 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for osteoporosis or other conditions that lead to low bone mass.
✕Less likely to help
Patients with normal bone density or those not affected by bone metabolism disorders may not benefit from this research.
What this research studies
This research investigates the roles of two different forms of Colony Stimulating Factor 1 (CSF1) in promoting bone growth in response to a hormone called PTH. The study uses animal models to understand how these forms of CSF1 interact with bone cells, particularly focusing on how they influence the activity of osteoclasts, which are cells that break down bone. By examining the effects of these CSF1 isoforms, the research aims to uncover mechanisms that could enhance bone formation and potentially lead to new therapies for low bone mass conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve bone density and health for patients with low bone mass.
How similar studies have gone: Previous research has shown promising results in understanding the roles of CSF1 in bone metabolism, suggesting that this approach has potential for significant advancements.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Insogna, Karl Leonard — Yale University
- Study coordinator: Insogna, Karl Leonard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.