Exploring Genes Connected to Type 2 Diabetes
Functional Interrogation of Type 2 Diabetes-associated Genetic Network
This project explores how specific genes linked to Type 2 Diabetes affect the body's ability to make and use insulin.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11194503 on NIH RePORTER |
What this research studies
This project uses advanced lab models, including human stem cells, to understand how genes related to Type 2 Diabetes work together. Researchers are creating special "islet organoids" from these stem cells to mimic the pancreas and see how genetic changes impact insulin production and cell health. They are also looking at specific genetic variations and how they might lead to problems in these cells. The goal is to uncover the detailed steps that lead to Type 2 Diabetes at a cellular level.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation, but future clinical trials stemming from this work would likely seek individuals with Type 2 Diabetes or those at high risk.
Not a fit: Patients not interested in the genetic causes of Type 2 Diabetes or those seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat Type 2 Diabetes by targeting these specific genetic pathways.
How similar studies have performed: While genome-wide association studies have identified many T2D-associated genes, understanding their complex interactions and cellular mechanisms using advanced stem cell models is a relatively new and promising approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Chen, Shuibing — Weill Medical Coll of Cornell Univ
- Study coordinator: Chen, Shuibing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.