Investigating genetic factors that affect insulin secretion in type 2 diabetes
Functional Interrogation of Type 2 Diabetes-associated Genetic Network
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11073518
This study is looking at how certain genes might affect insulin production in people with type 2 diabetes, using special lab techniques to better understand how these genes impact the cells that make insulin.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11073518 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific genetic variants contribute to type 2 diabetes by examining their effects on insulin secretion in pancreatic cells. Using advanced techniques like CRISPR and human pluripotent stem cells, the researchers will create models to study the interactions between these genetic factors and their impact on beta cell function. By analyzing how these genes influence insulin production and cell survival, the study aims to uncover the underlying mechanisms of type 2 diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes, particularly those with a genetic predisposition to the condition.
Not a fit: Patients with type 1 diabetes or those without any genetic factors associated with type 2 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for improving insulin secretion in patients with type 2 diabetes.
How similar studies have performed: Previous research using CRISPR and stem cell technologies has shown promise in understanding genetic contributions to various diseases, suggesting that this approach could yield valuable insights for type 2 diabetes as well.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, SHUIBING — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: CHEN, SHUIBING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus