Investigating genetic factors that affect insulin secretion in type 2 diabetes
Official title: Functional Interrogation of Type 2 Diabetes-associated Genetic Network
Funded at Weill Medical Coll of Cornell Univ · NIH-11073518 · Data updated 2026-11-12
This study is looking at how certain genes might affect insulin production in people with type 2 diabetes, using special lab techniques to better understand how these genes impact the cells that make insulin.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 19, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $561,893 |
| NIH project number | 1R01DK142414-01 |
| Project ID | NIH-11073518 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes, particularly those with a genetic predisposition to the condition.
✕Less likely to help
Patients with type 1 diabetes or those without any genetic factors associated with type 2 diabetes may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic variants contribute to type 2 diabetes by examining their effects on insulin secretion in pancreatic cells. Using advanced techniques like CRISPR and human pluripotent stem cells, the researchers will create models to study the interactions between these genetic factors and their impact on beta cell function. By analyzing how these genes influence insulin production and cell survival, the study aims to uncover the underlying mechanisms of type 2 diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for improving insulin secretion in patients with type 2 diabetes.
How similar studies have gone: Previous research using CRISPR and stem cell technologies has shown promise in understanding genetic contributions to various diseases, suggesting that this approach could yield valuable insights for type 2 diabetes as well.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Chen, Shuibing — Weill Medical Coll of Cornell Univ
- Study coordinator: Chen, Shuibing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.