Exploring brain cell behavior in multiple sclerosis using advanced imaging techniques
Official title: In vivo three-photon microscopy of the cortical gray and white matter
Funded at University of Colorado Denver · NIH-11092786 · Data updated 2026-11-12
This study is looking at how multiple sclerosis affects the brain and how special cells that help repair nerve coverings behave, and it invites MS patients to help researchers learn more about their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | July 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $530,562 |
| NIH project number | 5R01NS132859-03 |
| Project ID | NIH-11092786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are adults aged 21 and older who have been diagnosed with multiple sclerosis.
✕Less likely to help
Patients who do not have multiple sclerosis or are under the age of 21 may not receive any benefit from this research.
What this research studies
This research investigates how multiple sclerosis (MS) affects different regions of the brain, particularly focusing on the behavior of oligodendrocytes, which are crucial for myelin repair. By utilizing advanced three-photon microscopy, researchers aim to visualize and monitor these cells in real-time within the living brain. This approach allows for a deeper understanding of how oligodendrocytes behave in both gray and white matter, which could lead to new insights into the mechanisms of MS and potential therapeutic strategies. Patients with MS may have the opportunity to contribute to this groundbreaking research by providing insights into their condition.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for multiple sclerosis by enhancing our understanding of brain cell behavior and repair mechanisms.
How similar studies have gone: Previous research using advanced imaging techniques has shown promise in understanding brain cell dynamics, suggesting that this approach could yield valuable insights into MS.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Hughes, Ethan Garrett — University of Colorado Denver
- Study coordinator: Hughes, Ethan Garrett
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.