Time-of-day exercise and social jetlag: protecting the heart and metabolic health
Official title: Effects of time-of-day dependent exercise training on social jetlag induced susceptibility to cardiometabolic disease
Funded at University of Nevada Las Vegas · NIH-11386467 · Data updated 2026-11-12
A study to see if misaligned daily schedules (social jetlag) reduce the benefits of exercise on heart and metabolic health in adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Las Vegas NIH-funded |
| Lab location | 1 site (Las Vegas, United States) |
| Project start | August 4, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $189,375 |
| NIH project number | 5R16GM150488-04 |
| Project ID | NIH-11386467 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults experiencing social jetlag or irregular work/school schedules who are willing to participate in supervised exercise programs.
✕Less likely to help
Individuals without social jetlag or those not able to participate in exercise training may see no direct benefit.
What this research studies
This project will examine whether chronic social jetlag makes people less responsive to exercise training and increases their risk of developing cardiometabolic problems. By comparing exercise outcomes in individuals with varying degrees of weekday–weekend schedule differences, researchers will look at heart function, weight, and metabolic markers. The study builds on prior findings that exercise timing can affect heart biology, and it aims to identify when exercise is most protective for people whose circadian rhythms are disrupted. The goal is to inform personalized exercise prescriptions to prevent cardiovascular and metabolic diseases.
Why it matters
Potential benefit: If successful, the findings could lead to more effective exercise recommendations for people with irregular schedules, potentially reducing heart disease and diabetes risk.
How similar studies have gone: Previous work suggests timing and circadian factors influence exercise responses, but the impact of chronic social jetlag on training adaptations is not yet fully understood.
Where this research is happening
-
University of Nevada Las Vegas
Las Vegas, United States Active
Researchers
- Principal investigator: Mcginnis, Graham Ripley — University of Nevada Las Vegas
- Study coordinator: Mcginnis, Graham Ripley
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.