Effects of hormonal contraception on brain function and behavior

Neurobiology of hormonal contraception

NIH-funded research University of Colorado Denver · NIH-11011440

This study is looking at how a common birth control pill affects women's motivation and sexual feelings, to help find ways to make contraception better and more comfortable for everyone.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Colorado Denver NIH-funded
Lab location1 site (Aurora, UNITED STATES)
Project IDNIH-11011440 on NIH RePORTER

What this research studies

This research investigates how hormonal contraception, specifically the oral contraceptive containing ethynyl estradiol and levonorgestrel, affects brain reward processing and related behaviors in women. By using a placebo-controlled design, the study aims to understand the impact of these hormones on motivation and sexual function, which are critical factors influencing the use and discontinuation of contraceptives. The findings could lead to personalized treatment options that minimize negative side effects associated with hormonal contraception, ultimately improving patient satisfaction and adherence.

Who could benefit from this research

Good fit: Ideal candidates for this research are reproductive-aged women who are considering or currently using hormonal contraception.

Not a fit: Patients who are not using hormonal contraception or those who have contraindications to its use may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved hormonal contraceptive options that reduce negative mood and decreased sexual desire, enhancing overall patient satisfaction.

How similar studies have performed: Previous research has shown that hormonal treatments can significantly impact brain function and behavior, suggesting that this approach may yield valuable insights.

Where this research is happening

Aurora, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.