Sponsor or institution
Clinical trials and research at University of Illinois at Chicago
As of November 12, 2026, Find a Trial lists 728 NIH-funded research projects at this institution, with $398.9 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 728NIH research projects
NIH-funded research (newest 40 of 728)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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MSC Secretome Eye Drops to Speed Healing of Corneal Wounds
A new eye drop made from stem cell–secreted factors is being tested to help adults with non-healing corneal wounds recover vision faster.
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UIC Center for Healthy Work
A national program led by UIC aims to improve the health and well-being of workers through collaborative research and practical solutions.
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Coordinated Oral Health Promotion for Chicago Kids
A long-running study in Chicago is following children and their caregivers to find ways to reduce tooth decay and improve daily life for families.
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Targeting p38 MAPK to slow ALS-related axonal damage
Aims to block a specific brain-wide signaling pathway (p38 MAPK) to reduce nerve damage in people with various genetic forms of ALS.
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Precision nanomedicine to calm inflammation and protect bone in gum disease
A new, targeted nanomedicine approach aims to reduce gum inflammation and prevent bone loss in adults with periodontal disease.
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Role of DPP in Dental Pulp Stem Cells and their Regenerative Potential
A project explores how a natural tooth protein helps dental pulp stem cells repair and regenerate the tooth’s inner tissue.
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Illinois Occupation Health Surveillance program renewal
A state-level program continues to monitor occupational injuries and illnesses to identify new hazards and help shape policies to keep workers safe.
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Mindfulness-based Support for Pain and Sleep in Young People with Sickle Cell Disease
A digital mindfulness program is being tailored for adolescents and young adults with sickle cell disease to help with pain and sleep and is being tested for practicality and early effectiveness.
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Biomaterials and Ethics: Expanding Smart, Safe Innovations
A funding center is supporting projects that explore the ethical and social aspects of creating and using biomaterials in healthcare.
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Precision, data-driven guidance for taste loss in cancer patients
A smartphone-supported program uses data and sensors to diagnose, monitor, and guide dietary help for people with taste loss after head and neck cancer treatment.
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Role of TRIM2 and SIRPA in New World arenavirus entry
A study to understand how certain human genes help prevent the entry of dangerous New World arenaviruses into cells, with the goal of guiding future therapies.
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Protective dengue vaccines that steer T and B cell responses
A vaccine study aims to guide the body’s T and B cells to fight all four dengue virus types safely and effectively.
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Bone-like Organoids to Predict and Improve Craniofacial Bone Healing
Aimed at people needing craniofacial bone repair, this project uses bone-like organoids to study how the immune system affects healing and to improve outcomes after bone reconstruction.
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Nurse- and Peer-Led Suicide Prevention for Women in Tajikistan
A nurse- and peer-led program in Tajikistan aims to help women at risk of suicide by adding tailored, frontline support in primary care.
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UIC Maternal Health Center of Excellence brings together teams to improve maternal health in communities
A center-based program at UIC will work with communities and researchers to reduce maternal death and serious health problems by improving systems of care.
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Understanding how brain hyperexcitability and sex differences affect Alzheimer’s disease
This grant tests whether brain hyperexcitability linked to a genetic risk (APOE4) and sex differences contribute to memory decline in Alzheimer’s disease, using computer simulations and mouse data to guide potential human treatments.
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AI-powered tools to help youth choose PrEP and stay engaged in HIV prevention
A new NIH grant will test AI-assisted supports on a digital platform to help youths aged 13–24 learn about PrEP options, choose the right method, and access benefits.
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Understanding axon degeneration in hereditary spastic paraplegia and ALS using patient-derived neurons
Aimed at understanding why certain nerve fibers die in hereditary spastic paraplegia and ALS by studying neurons made from patients’ own stem cells.
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Site-based social network approach to find undiagnosed HIV, boost testing among men, and reduce stigma in South Africa
A new approach uses people with HIV to recruit a broader circle for HIV testing in South Africa, aiming to find undiagnosed cases, increase testing among men, and lower stigma.
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C-DOSETaP: A Data-Driven System to Improve OUD Screening, Care, and Planning in Chicago
A data-driven tool helps UI Health identify and support people at risk for opioid use disorder so they can get prevention, treatment, and recovery help.
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Prison-based HIV Partner Notification in Indonesia explains how to help inmates get partners tested
This grant tests a prison-based approach to help people with HIV in Indonesia inform their partners and link them to testing and care.
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Voltage clamp fluorometry of TMEM16A channels in axolotl oocytes
A small NIH grant is funding a study to better understand how TMEM16A channels behave in axolotl (ambystoma) oocytes so researchers can design better drugs to prevent stroke damage.
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Patient navigation to boost cervical cancer screening in Senegal
A patient-facing program helps women in rural Senegal get screened for cervical cancer, receive timely follow-up, and connect with care.
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Nurse-led group program to boost PrEP use for women at risk of HIV
A nurse-developed, three-session group program helps women in midwestern cities start and stay on PrEP to prevent HIV.
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Adapting an evidence-based workout program to slow frailty in older women living with HIV
A new program will tailor a proven physical activity plan to help older women with HIV stay stronger, more mobile, and less frail.
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Effects of prescription opioid use during pregnancy on a mother's brain after birth
This project looks at how taking prescription opioids during pregnancy changes a mother's brain and behavior after her baby is born.
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Clearer dental plaque with safe tiny particles to help kids’ teeth
A tiny, targeted treatment idea uses safe particles to help clear harmful plaque in young children to prevent early tooth decay.
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Understanding how a immune signal (CCL22-CCR4) helps fat cells become energy-burning beige fat
A study in mice and humans explores how an immune signal called CCL22 and its partner CCR4 help fat tissue turn into energy-burning beige fat, which could help combat obesity and diabetes.
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How increased neuron growth could help memory in Alzheimer's disease
Aims to understand how immature neurons in a brain area important for memory contribute to Alzheimer's symptoms and whether boosting their growth or activity could improve memory.
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Modularly Defined Stilbenoids to Strengthen Tooth Bonding
A science team is testing plant-based biopolymers to make dental fillings stick better and last longer, helping people with cavities.
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Irresistible blood-stage antimalarials for travelers, military personnel, and at-risk populations
A funded NIH grant is developing new, powerful malaria medicines that can kill all blood-stage parasites and help people at risk from traveler, military, or local transmission in the U.S. and beyond.
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Acupuncture for psychic and neural symptoms in breast cancer survivors
A study tests whether acupuncture helps improve joint pain, fatigue, and sleep problems in breast cancer survivors who are on endocrine therapy.
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Understanding how ArmA changes make bacteria resistant to common antibiotics
A short, patient-friendly look at how a specific bacterial resistance mechanism works and why it matters for antibiotic effectiveness.
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CNTNAP2: How a nerve protein may help ovarian cancer spread in the abdomen
A small NIH grant is studying whether a protein involved in nerves, CNTNAP2, helps ovarian cancer cells stick and spread in the abdomen.
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Neural and computational markers linked to reward that may predict cannabis use escalation in young adults with anhedonia
This study follows young adults with anhedonia to see how their brain responses to rewards and computational signals relate to increasing cannabis use over time.
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Teleassessment of gait and balance after stroke to expand remote rehabilitation
A multi-site study tests simple remote gait and balance tests for stroke survivors to enable safer, easier rehabilitation from home.
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Interpretable AI for Understanding How Cells Change in Cancers
A patient-facing explanation of a grant that uses smart computer models to understand how cancer cells change over time and in different environments to guide future treatments.
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Chemical membrane labeling and fluorescence-guided sequencing to decode how cells communicate via microvesicles
A new technique will label donor cells and read how microvesicles transfer messages between cancer cells and their surroundings, helping us understand how tumors grow and resist treatment.
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Neurovascular problems in sickle cell eye disease
This project looks at how blood vessel problems in sickle cell disease affect the retina and vision, with the goal of finding clearer ways to measure and track these changes.
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Miz1: How early endotoxin exposure could guard against allergic asthma and how we might use that idea to help patients
A study exploring how a molecule called Miz1 changes with early endotoxin exposure to reduce allergic asthma, with potential to lead to new prevention or treatment options for people with asthma.
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