Developing new algorithms to improve cryogenic electron microscopy for studying proteins
Official title: New Algorithms for Cryogenic Electron Microscopy
Funded at Yale University · NIH-10903713 · Data updated 2026-11-12
This study is working on improving a special imaging technique called cryogenic electron microscopy to help scientists see the shapes of proteins more clearly, which could lead to a better understanding of how proteins work and interact in our bodies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $418,750 |
| NIH project number | 5R35GM148072-02 |
| Project ID | NIH-10903713 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to protein misfolding or dysfunction, such as neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to protein structure or function may not receive direct benefits from this research.
What this research studies
This research focuses on enhancing cryogenic electron microscopy (Cryo-EM), a cutting-edge technique used to visualize the 3D structures of proteins. The team aims to create advanced algorithms that can accurately reconstruct the structures of small proteins and those that exist in multiple forms. By addressing challenges such as noise interference and resolution limits, the research seeks to improve the clarity and reliability of protein images obtained through Cryo-EM. This could lead to better understanding of protein functions and interactions at a molecular level.
Why it matters
Potential benefit: If successful, this research could significantly enhance the ability to visualize and understand protein structures, leading to advancements in drug development and disease treatment.
How similar studies have gone: Previous research has shown promising results in improving Cryo-EM techniques, indicating that advancements in this area could lead to significant breakthroughs.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Tagare, Hemant D — Yale University
- Study coordinator: Tagare, Hemant D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.