Developing drugs to inhibit HPV replication
Official title: Small Compound Inhibitors Targeting HPV Genome Replication
Funded at Ut Southwestern Medical Center · NIH-11048913 · Data updated 2026-11-12
This study is looking for new ways to stop the human papillomavirus (HPV) from spreading, which can cause certain cancers, by targeting a specific protein that helps the virus replicate, and it aims to create treatments that could help people, especially those who can't or don't want to get vaccinated.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $660,205 |
| NIH project number | 1R01CA288743-01A1 |
| Project ID | NIH-11048913 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who are at risk for HPV-related cancers or have been diagnosed with HPV infections.
✕Less likely to help
Patients who have already been effectively treated for HPV-related conditions or those who are not infected with HPV may not benefit from this research.
What this research studies
This research focuses on finding small compound inhibitors that can block the replication of the human papillomavirus (HPV), which is linked to several cancers, including cervical and anal cancer. The approach involves targeting a specific protein, BRD4, that plays a crucial role in HPV's ability to replicate and affect host cells. By understanding how BRD4 interacts with HPV, the researchers aim to develop new antiviral therapies that could help manage HPV-related diseases. Patients may benefit from these therapies, especially those who are unable to receive vaccines or have vaccine hesitancy.
Why it matters
Potential benefit: If successful, this research could lead to new antiviral treatments for patients affected by HPV-related cancers.
How similar studies have gone: Other research has shown promise in targeting viral replication mechanisms, suggesting that this approach could be effective.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Chiang, Cheng-Ming — Ut Southwestern Medical Center
- Study coordinator: Chiang, Cheng-Ming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.