Developing a new male contraceptive method.
Targeting the MEIG1/PACRG interaction for male contraception.
This study is working on a new kind of male birth control that stops sperm production without hormones, by targeting specific proteins involved in sperm development, and it could offer a safe and reversible option for men.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10705689 on NIH RePORTER |
What this research studies
This research aims to create a male contraceptive that effectively blocks sperm production without using hormones, which can cause unwanted side effects. The focus is on disrupting the interaction between two proteins, MEIG1 and PACRG, that are crucial for sperm development. By using advanced techniques, including artificial intelligence, the researchers will screen for small molecules that can inhibit this protein interaction, potentially leading to a safe and reversible contraceptive option for men.
Who could benefit from this research
Good fit: Ideal candidates for this research are healthy males who are seeking contraceptive options.
Not a fit: Patients who are not male or those who are not interested in male contraception may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide men with a reliable and non-invasive contraceptive method.
How similar studies have performed: While male contraception research has faced challenges, this approach targeting specific protein interactions is innovative and has not been widely tested in previous studies.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Zhang, Zhibing — Wayne State University
- Study coordinator: Zhang, Zhibing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.