Creating personalized treatment plans for severe ulcerative colitis
Official title: Development of Patient-Tailored Adaptive Treatment Strategies for Acute Severe Ulcerative Colitis
Funded at University of Michigan at Ann Arbor · NIH-11059232 · Data updated 2026-11-12
This study is looking at new ways to personalize treatment for people with acute severe ulcerative colitis, so that each patient gets the best care based on how they respond to different medications, helping to improve their recovery and avoid emergency surgeries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 14, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $194,400 |
| NIH project number | 5K23DK134764-03 |
| Project ID | NIH-11059232 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 18 and older who are experiencing acute severe ulcerative colitis.
✕Less likely to help
Patients with mild ulcerative colitis or those who do not meet the age requirement may not benefit from this research.
What this research studies
This research focuses on developing adaptive treatment strategies tailored to individual patients suffering from acute severe ulcerative colitis (ASUC). The approach aims to address the limitations of current one-size-fits-all treatments by considering the unique responses and clinical changes of each patient. By utilizing a combination of therapies, including corticosteroids and rescue medications, the research seeks to improve treatment outcomes and reduce the need for emergency surgeries. Patients will be monitored closely to adjust their treatment plans based on their specific needs and responses.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with acute severe ulcerative colitis.
How similar studies have gone: Previous research has shown promise in developing personalized treatment strategies for inflammatory bowel diseases, indicating potential success for this approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Berinstein, Jeffrey — University of Michigan at Ann Arbor
- Study coordinator: Berinstein, Jeffrey
Related research
Other NIH-funded projects on the same topics.
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Outpatient pathway for severe ulcerative colitis in the right care setting
This study tests a safe, outpatient approach using an oral therapy and remote monitoring for people with acute severe ulcerative colitis to avoid hospitalization.
-
Fh15-based therapy to calm inflammation in sepsis and ulcerative colitis
A research project tests a molecule from a parasitic organism (Fh15) to reduce harmful inflammation in adults with sepsis or ulcerative colitis.
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IMYX-3 treatment for ulcerative colitis
A new therapy approach called IMYX-3 aims to help adults with moderate to severe ulcerative colitis who have not responded well to current treatments.
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This NIH grant aims to understand how antibodies against a gut cell protein (αvβ6) may actively contribute to ulcerative colitis and what that means for future treatments.
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Selenium supplementation to help moderate-severe ulcerative colitis flare-ups
This grant tests whether giving selenium can help people with moderate to severe ulcerative colitis reduce flares and improve symptoms.
-
Development of TP-317 for Ulcerative Colitis
A new therapy approach for ulcerative colitis aims to repair the intestinal lining and restore immune balance in people with UC, addressing a need for patients who don’t fully respond to current treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.