Creating new mouse strains quickly using advanced gene editing techniques
Official title: Rapid Development of Mouse Resource Strains through the Application of Prime Editors
Funded at Jackson Laboratory · NIH-10952278 · Data updated 2026-11-12
This study is working on a quicker and easier way to create special mice that help scientists understand human diseases better, which could eventually lead to improved treatments for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $265,500 |
| NIH project number | 1R21OD037653-01 |
| Project ID | NIH-10952278 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with genetic disorders or diseases that are being studied using mouse models.
✕Less likely to help
Patients who do not have conditions that are modeled in mice or those who are not involved in genetic research may not receive direct benefits from this research.
What this research studies
This research focuses on developing a faster and more efficient method for creating genetically modified mouse strains using a technology called prime editing. By combining functional DNA sequences with thousands of unique mouse genes, the researchers aim to streamline the process of generating these resources, which has traditionally been labor-intensive and costly. This approach could significantly reduce the time and expense involved in creating mouse models that are essential for studying human diseases and genetic functions. Patients may benefit indirectly as these improved models can lead to better understanding and treatment of various conditions.
Why it matters
Potential benefit: If successful, this research could lead to quicker development of mouse models that enhance our understanding of human diseases, potentially accelerating the discovery of new treatments.
How similar studies have gone: Other research has shown success with similar gene editing technologies, indicating a promising potential for this novel approach.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Bergstrom, David Eric — Jackson Laboratory
- Study coordinator: Bergstrom, David Eric
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.