Connecting tiny brain structures to brain activity in humans and primates
Tools for integrating brain microstructure with functional dynamics in human and non-human primates
This project builds software tools that link small-scale brain structure to brain activity to help researchers understand brain function and disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Child Mind Institute, INC. NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11325436 on NIH RePORTER |
What this research studies
Researchers will extend a tool called BrainBuilder to create 3D maps of microstructure across the whole human and macaque brain, including cortex and subcortex. They will enhance Neuromaps software to bring together multi-scale imaging, molecular information, and cross-species comparisons so brain annotations can be transformed between reference spaces. The tools will let scientists link microstructural features to MRI BOLD signals and molecular data to run computer-based experiments about how structure shapes brain dynamics. This project uses existing human imaging and mesoscale tissue data rather than enrolling patients directly.
Who could benefit from this research
Good fit: This project does not enroll patients; it relies on existing human brain images and tissue datasets contributed by research centers.
Not a fit: People seeking immediate treatment or clinical interventions should not expect direct benefit from this work.
Why it matters
Potential benefit: If successful, these tools could help researchers spot structural markers of brain disorders and suggest new targets for treatments.
How similar studies have performed: Related brain atlasing and mapping projects exist, but this full-cerebrum, cross-species integration with molecular enrichment is relatively novel.
Where this research is happening
New York, United States
- Child Mind Institute, INC. — New York, United States (Active)
Researchers
- Principal investigator: Funck, Thomas — Child Mind Institute, INC.
- Study coordinator: Funck, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.