Clinical Core for Alzheimer's disease research coordination and data integration
Official title: Clinical Core
Funded at Northern California Institute/res/edu · NIH-11395202 · Data updated 2026-11-12
A large, long-term NIH grant supports coordinating clinical activities and data collection for Alzheimer's disease research to improve trials and understanding of the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 30, 2004 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $11,859,096 |
| NIH project number | 5U19AG024904-19 |
| Project ID | NIH-11395202 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with or at risk for Alzheimer’s disease, including cognitively normal adults, people with mild cognitive impairment, and those with dementia who participate in longitudinal follow-up and web-based assessments.
✕Less likely to help
Patients not involved in follow-up visits or web-based assessments, or those outside the ADNI network, may see less direct benefit.
What this research studies
This grant funds the Clinical Core of the ADNI project, handling day-to-day clinical operations, regulatory oversight, site management, and data coordination across multiple sites. It emphasizes maintaining and enriching the ADNI cohort, including cognitively normal individuals, people with mild cognitive impairment, and those with dementia, to maximize the long-term value of the dataset. New participants are recruited through a web-based cohort and novel cognitive and sociocultural assessments are being added, with most assessments carried forward into future study phases to preserve longitudinal continuity. Researchers aim to illuminate how cognitive, clinical, biofluid, and imaging markers relate to disease progression and trial design.
Why it matters
Potential benefit: If successful, the work could sharpen designs for future Alzheimer’s trials and improve our understanding of disease progression through richer, long-term clinical data.
How similar studies have gone: Previous ADNI efforts have generated foundational insights into Alzheimer’s biomarkers and trial design, with continued value from longitudinal data.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Aisen, Paul S. — Northern California Institute/res/edu
- Study coordinator: Aisen, Paul S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.